Tracking low-risk endometrial cancer outcomes with minimal lymph node involvement

Plain-English translation of NCT06689956 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This study is watching people who have been treated for early-stage endometrial cancer and had very small amounts of cancer cells discovered in their lymph nodes during surgery. Researchers want to understand whether these patients do just as well without additional chemotherapy or radiation as patients who had no cancer cells in their lymph nodes at all. By comparing outcomes over time, this research may help doctors decide which patients truly need extra treatment and which can safely avoid it.

Doctors are uncertain whether patients with tiny amounts of cancer in their lymph nodes need additional treatment after surgery. This study exists to answer that question by carefully tracking what happens to these patients over time, potentially sparing some from unnecessary treatment while keeping them safe.

Do you qualify?

You likely qualify if…

you have been diagnosed with low-risk endometrial cancer (grade 1 or 2, stage IA)
you had surgery that included removal and testing of sentinel lymph nodes
your pathology report shows only isolated tumor cells (very small amounts of cancer, 0.2 mm or smaller) in your lymph nodes
you have minimal or no lymph-vascular invasion (fewer than 5 blood vessels involved)
you have not received and do not plan to receive chemotherapy or radiation after your surgery

You likely don't qualify if…

you received chemotherapy before your cancer surgery
you are planning to receive chemotherapy or radiation after surgery
you have another active cancer diagnosis (other than non-melanoma skin cancer)
you have larger amounts of cancer in your lymph nodes (larger than isolated tumor cells)
you had a different invasive cancer diagnosis within the past 5 years

What participation looks like

As a participant, you would allow researchers to collect a small tissue sample and review your medical records to track how you are doing over time. There are no extra visits, medications, or procedures — this is purely observational, meaning researchers are watching and documenting your health outcomes rather than giving you a new treatment. The study will compare your outcomes to historical records of similar patients who had no cancer cells in their lymph nodes.

AI-generated summary from trial data · Jun 13, 2026 · Not medical advice

Trial locations(20 sites)

United States

Mayo Clinic in Rochester, Rochester, Minnesota

Memorial Sloan Kettering Cancer Center, New York, New York

Houston Methodist Hospital, Houston, Texas

Austria

Medical University of Vienna, Vienna

Brazil

AC Camargo Cancer Center, São Paulo