Plain-English translation of NCT06693986 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is an early-stage study testing a new approach to pancreatic cancer treatment using RGDCRAdCOX2F, a genetically modified virus that is injected directly into the tumor. The virus is designed to infect and kill cancer cells while leaving healthy tissue alone. Researchers are trying to find the right dose that works safely and effectively.
Pancreatic cancer is very difficult to treat because tumors are often in hard-to-reach locations inside the body. By injecting this medication directly into the tumor during an endoscope procedure, doctors hope to deliver powerful treatment right where the cancer is, rather than relying on systemic chemotherapy alone.
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You would visit the University of Minnesota's Masonic Cancer Center for an endoscopic ultrasound procedure, during which doctors inject the modified virus directly into your pancreatic tumor. The study enrolls patients in small groups and monitors you carefully for side effects over at least 28 days. You may be asked to return for follow-up visits and tests to see how your body tolerates the treatment and whether the tumor responds.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Masonic Cancer Center, University of Minnesota
Enrollment target
~18 participants
Started
December 2024
Primary completion
October 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
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Central contact
Edward Greeno, MD
Masonic Cancer Center, University of Minnesota
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