Combining immunotherapy with focused radiation for lung cancer spread to the brain

This trial is testing whether cadonilimab, an immunotherapy medication, works better when combined with stereotactic radiotherapy (a type of highly focused radiation) for treating brain metastases—places where lung cancer has spread to the brain. The idea is that the radiation therapy may help boost the immune system's ability to fight cancer, while the medication helps the immune system recognize and attack cancer cells.

When lung cancer spreads to the brain, standard treatments don't always work well, and patients often need new options. This trial explores whether combining radiation with immunotherapy could be more effective than either treatment alone, especially for patients whose cancer has already resisted one round of treatment.