Recruiting

Building a research database of brain health across ages

Plain-English translation of NCT06703541 on ClinicalTrials.gov ↗ · Source last updated August 2025 · Translation generated June 2026 · How we translate trials

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What is this trial?

This is a research study that follows people ages 25–80 who have normal thinking, mild memory problems, or Alzheimer's disease. Researchers will collect baseline information including medical history, memory tests, brain scans, and blood samples to build a database. Over time, participants aged 45–80 will return yearly for follow-up visits so doctors can track how thinking and brain health change.

Scientists need long-term information from real patients to understand how Alzheimer's disease develops, how age and genetics affect brain health, and what early warning signs might predict problems. This database will help researchers learn more about the disease and potentially discover better ways to diagnose and treat it.

Do you qualify?

You likely qualify if…

you are between ages 25 and 80 at enrollment
you can read at approximately a 6th-grade level
you are willing to have an MRI brain scan and either a lumbar puncture (spinal tap) or a series of PET scans
if you are 45–80 years old, you have a study partner (a family member or close friend) who will also participate

You likely don't qualify if…

you have a serious or unstable neurological condition such as multiple sclerosis, Parkinson's disease, or a history of multiple strokes
you have a serious or unstable psychiatric condition
you have struggled with alcoholism or drug abuse in the past 2 years
you have had cancer (other than skin cancer) treated in the past 5 years
you have an implanted device (like a pacemaker) or other condition that prevents you from safely having an MRI

What participation looks like

At your first visit, you will complete a full medical exam, memory and thinking tests, have blood and urine samples taken, and undergo an MRI brain scan and either a spinal tap or PET scans. If you are 45–80, your study partner will also participate. Participants aged 45–80 will return every year for follow-up visits that include updated medical history, another physical exam, and repeat memory testing. A research team will review your results yearly to confirm your diagnosis.

Building a research database of brain health across ages

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)