Plain-English translation of NCT06705296 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our PTSD research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is the first clinical trial testing deep brain stimulation (DBS) for people with severe, long-lasting PTSD that hasn't responded to standard medications and therapy. DBS is a surgical procedure where doctors place a small device in your brain that sends gentle electrical signals to help regulate brain activity related to trauma responses. Researchers hope this treatment will reduce PTSD symptoms in people who haven't benefited from other approaches.
Despite decades of research and many treatment options, some people with PTSD continue to suffer severely and don't improve with available medications or talk therapy. Scientists have discovered that PTSD involves problems in specific brain circuits, and this treatment is designed to directly target and help normalize those circuits—an approach that has already shown promise for treating depression, which often occurs alongside PTSD.
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If you join this study, you'll first undergo detailed evaluations including brain imaging (MRI), memory and thinking tests, and assessments by an anesthesia team. Then you'll have the surgical procedure to place the brain stimulation device. After surgery, you'll be monitored for about 60 weeks (roughly 14 months) during which the device will be turned on, then briefly turned off so researchers can compare your symptoms, and you may also receive additional therapy. Throughout this time, you'll have regular clinic visits, brain imaging, and psychological testing to measure how you're doing.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
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