Understanding immune system changes in Lynch syndrome patients

This research study is trying to understand how your immune system works in Lynch syndrome — specifically, whether certain immune markers in your blood can predict who is at highest risk for developing colorectal cancer. Researchers will collect blood and tissue samples from people with Lynch syndrome, both those who have developed cancer or precancerous growths and those who have not, to compare these immune markers between groups.

People with Lynch syndrome have a very high risk of colorectal cancer even when they receive regular screening colonoscopies. By identifying early immune markers that signal cancer development, doctors may be able to identify which patients need more intensive monitoring or new preventive treatments in the future.