Plain-English translation of NCT06709885 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This clinical trial is testing whether chidamide—a new type of drug—combined with immunotherapy and standard chemotherapy can better treat locally advanced colon cancer before surgery. Right now, doctors use chemotherapy and immunotherapy together to shrink tumors before operating. This study asks: does adding chidamide to that combination work even better, and is it safe?
Standard chemotherapy and immunotherapy help some patients with advanced colon cancer, but doctors want to know if this medication can improve results—helping more tumors shrink completely and giving patients better long-term outcomes.
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You will be randomly assigned to one of two groups. One group receives chidamide plus immunotherapy plus chemotherapy; the other receives chemotherapy and immunotherapy alone. Both groups receive 4 treatment cycles, with each cycle lasting 3 weeks. You will receive intravenous infusions on specific days and take oral pills at home. After completing the 4 cycles, you will have surgery to remove the tumor. Throughout the study, you will have regular blood tests and imaging scans to monitor how the treatment is working and check for side effects.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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