Plain-English translation of NCT06716489 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Migraine research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a combination of supervised aerobic exercise and pain neuroscience education can help reduce migraine symptoms and disability in women. Migraine is a complex neurological disorder that affects not just headache frequency, but also body sensitivity, muscle function, and emotional well-being. This study will compare women who receive supervised exercise three times per week plus education about how migraine works against women who receive general recommendations for home-based physical activity.
While exercise and education are known to help with migraine, researchers have not fully studied how well they work together, or how they affect the body's sensitivity and muscle function. This trial aims to fill that gap and provide evidence that exercise combined with education could be a safe, accessible treatment option for migraine.
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If you are chosen for the exercise group, you will attend one 60-minute educational session learning about how migraine works and the importance of safe movement, then participate in supervised aerobic exercise (on a treadmill) three times per week for 16 weeks. Each session includes a warm-up, aerobic training, cool-down, and stretching. You will also complete questionnaires and physical assessments at the start, end of 16 weeks, and again at 6 months. If you are in the control group, you will receive recommendations to exercise at home on your own during the same period and complete the same assessments.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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