Combining chemotherapy, immunotherapy, and radiation before lung cancer surgery

Plain-English translation of NCT06718309 on ClinicalTrials.gov ↗ · Source last updated December 2024 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new approach for treating advanced lung cancer that can be surgically removed. You would receive combined with (a treatment that helps your immune system fight cancer), followed by a focused radiation treatment to the tumor, then more and . After this preparation, you would have surgery to remove the cancer, followed by a year of maintenance to help prevent the cancer from returning.

For patients with advanced lung cancer that can be removed by surgery, doctors want to find the best way to shrink the tumor before surgery and reduce the chance that cancer comes back. This trial combines three powerful treatments to see if attacking the cancer from multiple directions before surgery improves outcomes.

Do you qualify?

You likely qualify if…

you have been newly diagnosed with non-small cell lung cancer confirmed by biopsy or pathology
you are 18 years or older and in good enough health to tolerate treatment and surgery
your cancer is at stage II, IIIA, or certain stage IIIB types and can be surgically removed
your cancer cells do not have EGFR or ALK genetic mutations
you have not received any chemotherapy, immunotherapy, or chest radiation before
your blood counts, liver function, and kidney function are at acceptable levels

You likely don't qualify if…

you have severe heart, lung, or organ problems that would make surgery unsafe
you have an active autoimmune disease such as rheumatoid arthritis, lupus, or inflammatory bowel disease
you have had another cancer in the past 5 years (except skin cancer or cervical cancer)
you have an active infection, heart failure, or recent heart problems in the last 6 months
you are allergic to PD-1 inhibitors or have HIV, a history of organ transplant, or immune system disorders

What participation looks like

You would start with one cycle of plus , then receive focused radiation therapy to your lung tumor. After that, you would have two more cycles of the combined and . Between 4 and 6 weeks after your last treatment, you would have surgery to remove the cancer. Following surgery, you would continue alone as maintenance treatment for one year. Throughout this time, you would have regular visits for exams, blood tests, and scans to monitor how you are responding to treatment.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Trial locations(1 site)

China

Department of Thoracic Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang