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Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
After a stroke, many people develop shoulder pain and stiffness on the affected side. This trial is testing whether hyaluronidase—an enzyme that breaks down buildup in muscle tissue—can help reduce this pain when injected directly into the shoulder muscles. Researchers will compare people who receive the treatment injection to those who receive a placebo (saline only) to see if it truly makes a difference.
Shoulder pain after stroke is common and can be caused by changes in the muscle and connective tissue around the shoulder joint. Current treatments don't work well for everyone, so researchers are exploring whether this medication might help by breaking down the tissue buildup that contributes to the problem.
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You will receive one injection into your shoulder muscles—either the experimental medication or saline. The study team will take MRI scans and ultrasound images of your shoulder before the injection and again 5–7 weeks later to measure changes in the muscle tissue. You will also complete questionnaires and movement tests to assess your pain level, how far you can move your shoulder, and how well your arm is functioning. The entire study lasts several weeks, with your main visits being the injection appointment and the follow-up testing session.
AI-generated summary from trial data · Aug 15, 2026 · Not medical advice
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