Recruiting

Testing three drugs together for breast cancer that has spread to the brain

Plain-English translation of NCT06718933 on ClinicalTrials.gov ↗ · Source last updated February 2025 · Translation generated July 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a three-drug combination—, , and —to treat advanced breast cancer that has spread to the brain. The study happens in two phases: first, researchers will find the safest and most effective dose of the first two drugs together, then test all three drugs together in a larger group of patients to see how well they work.

Breast cancer that spreads to the brain is very difficult to treat, and there are limited options available. This trial explores whether combining these three medications might offer better results than current treatments for patients facing this serious situation.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with advanced breast cancer with confirmed brain metastases (spread to the brain) that have not been treated with radiation
you have a life expectancy of at least 3 months
you are in good enough overall health to tolerate the treatment, with adequate organ and bone marrow function
you have recovered from side effects of any prior cancer treatments (except hair loss or skin discoloration)

You likely don't qualify if…

you have cancer that has spread to the membranes surrounding your brain or spinal cord
you have uncontrolled fluid buildup in your abdomen, lungs, or around your heart
you have severe, uncontrolled brain symptoms like dangerously high pressure inside your skull, severe psychiatric symptoms, or uncontrolled seizures
you have had whole-brain radiation, chemotherapy, or brain surgery within the past 2 weeks
you have moderate-to-severe lung disease or a history of severe inflammation of lung tissue

What participation looks like

If you qualify, you'll be enrolled in one of two phases. In the first phase, you'll take the two medications at different doses to help researchers determine the safest and most effective dose level. In the second phase, you'll take all three medications together at the confirmed safe dose. You'll have regular visits to monitor how the treatment is working, check for side effects, and undergo scans to measure any changes in your brain tumors.

AI-generated summary from trial data · Jul 3, 2026 · Not medical advice

Trial locations(1 site)

China

Fudan Cancer Hospital, Shanghai, Shanghai Municipality