Plain-English translation of NCT06719947 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing a treatment called high-definition transcranial direct current stimulation (HD-tDCS) in people with amyotrophic lateral sclerosis (ALS). The treatment uses small electrical currents applied through electrodes on your scalp to stimulate the part of your brain that controls your breathing muscles. Researchers want to see if this treatment can help improve lung function and slow how quickly ALS progresses.
ALS gradually weakens the muscles you use to breathe, which is a serious concern for patients. Current treatments have limited ability to help with breathing problems, so researchers are exploring whether this non-invasive brain stimulation might offer a new way to protect and strengthen the muscles involved in breathing.
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If you enroll, you will be randomly assigned to receive either real or sham (fake) brain stimulation. You'll complete 10 sessions over two weeks, with one session each day, five days a week—all done from your home. Each session involves placing electrodes on your scalp over the area that controls breathing, with a gentle electrical current applied for a set period. Before, during, and after the treatment period, you'll have various breathing tests and evaluations to see if the treatment helps.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
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