Plain-English translation of NCT06722196 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether two small patches soaked with amiodarone hydrochloride—a medication that helps regulate heart rhythm—can prevent a common heart rhythm problem called atrial fibrillation that develops after heart surgery. The patches are placed directly on the heart during surgery and are designed to slowly release the medication where it's needed most. Half of the 500 participants will receive patches with the active medication, while the other half will receive patches with salt water only, so researchers can compare results fairly.
Atrial fibrillation is a very common complication after heart surgery, affecting many patients and potentially causing serious health problems. Doctors want to find a better way to prevent this rhythm problem, and this medication delivered directly to the heart tissue during surgery may offer a safer, more targeted approach than giving the drug throughout the whole body.
You likely qualify if…
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If you enroll, you'll be randomly assigned to receive either the medicated patches or salt-water patches during your scheduled heart surgery—you won't know which you received. The patches are placed on the heart during your operation and will gradually break down and be absorbed by your body. After surgery, you'll be monitored for any signs of irregular heartbeat, as you would normally be after heart surgery, and researchers will track whether you develop the rhythm problem in the weeks and months following your operation.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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