Plain-English translation of NCT06722521 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether a combination of two cholesterol-lowering medications—pitavastatin and ezetimibe—given at a higher dose without aspirin can protect your heart as well as a lower dose of pitavastatin combined with aspirin. You would be eligible if you have calcium deposits in your heart arteries (detected by a special scan) but no current symptoms or blockages, and doctors want to prevent future heart problems before they start.
Aspirin has long been used to prevent heart attacks in people at risk, but recent research suggests it may cause more bleeding problems than benefits in people without symptoms. This study is testing whether taking stronger cholesterol-lowering medication instead might provide better protection without the bleeding risks.
You likely qualify if…
You likely don't qualify if…
You would be randomly assigned to one of two groups: one taking the higher-dose combination medication without aspirin, or the other taking the standard-dose medication with aspirin. You would take your assigned medication daily and visit the clinic periodically so doctors can check your cholesterol levels, monitor how well the treatment is working, and watch for any side effects over the course of the study.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
South Korea
Phase
Post-approval monitoring
Sponsor
Asan Medical Center
Enrollment target
~7,435 participants
Started
July 2025
Primary completion
June 2032
Age range
19 Years and older
Last updated on clinicaltrials.gov in August 2025.
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Central contact
Seung-Whan Lee
Asan Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.