Recruiting

Testing a new cancer treatment for advanced solid tumors

Plain-English translation of NCT06723236 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

This is one of the first times this treatment has been tested in people.

What is this trial?

This is a first-in-human study of , an experimental medication designed to treat advanced solid tumors—including lung, bile duct, pancreatic, and colorectal cancers—that are no longer responding to standard therapy. The study will gradually increase the dose of in different groups of participants to find the safest and most effective dose. Researchers want to understand what side effects occur and whether this medication can shrink tumors or slow cancer growth.

There are currently limited treatment options for people whose cancers have stopped responding to standard therapy. This medication targets a protein called ADAM9 that is found on certain cancer cells, and early research suggests it may help control advanced cancers.

Do you qualify?

You likely qualify if…

you have been diagnosed with advanced lung adenocarcinoma, bile duct cancer, pancreatic cancer, or colorectal cancer that has not responded to standard treatment or for which standard treatment is not available
your cancer cannot be removed by surgery and has either spread to nearby tissues or to other parts of your body
you have cancer cells that can be measured on imaging scans
you are willing to provide a tumor sample (either from a previous biopsy or a new one) for research testing
you have acceptable overall health and normal or near-normal blood test results

You likely don't qualify if…

you have active cancer that has spread to your brain or the lining around your brain
you have received a stem cell transplant, tissue transplant, or organ transplant in the past
you have an active viral, bacterial, or fungal infection
you have had another cancer requiring treatment within the past 2 years (except for certain low-risk skin cancers or very early-stage prostate cancer)
you are pregnant, breastfeeding, or planning to become pregnant

What participation looks like

You will visit the clinic regularly to receive the medication as an intravenous infusion every 3 weeks. During each visit, you will have blood tests and physical exams, including heart and lung function checks, and your doctor will ask about any side effects. Your tumors will be measured regularly with imaging scans to see how you are responding to the treatment. The study will continue until your cancer progresses, you experience intolerable side effects, or your doctor determines it is in your best interest to stop.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Testing a new cancer treatment for advanced solid tumors

What is this trial?

Do you qualify?

What participation looks like

Trial locations(7 sites)