Tracking severe lung disease patterns across Brazil

Plain-English translation of NCT06724315 on ClinicalTrials.gov ↗ · Source last updated June 2025 · Translation generated June 2026 · How we translate trials

What is this trial?

This is a research study that follows people with severe chronic obstructive pulmonary disease (COPD) across eight hospitals in different regions of Brazil. Researchers want to understand how severe COPD affects patients over time and how different environments—like air pollution, smoking, and biomass burning—may influence the disease in different parts of the country. You would be monitored over 12 months to help doctors learn more about this condition.

COPD is a serious lung disease that affects many Brazilians differently depending on where they live and their exposure to environmental factors. This study exists to understand patterns in how severe COPD progresses and how regional differences influence the disease, so doctors can better care for patients.

Do you qualify?

You likely qualify if…

you have been diagnosed with severe or very severe COPD according to medical guidelines
you have significant difficulty breathing or experience at least 2 flare-ups per year (or 1 that required hospitalization)
your lung function test results show an FEV1 (a measure of how much air your lungs can move) less than 50% of normal
you are willing to visit a hospital for check-ups at the start, and at 6 and 12 months
you can participate in brief phone or virtual check-ins at 3 and 9 months

You likely don't qualify if…

you have severe scarring in your lungs (interstitial lung disease) covering more than half of your lung tissue
you have severe high blood pressure in your lung blood vessels and are on three different medications for it
you are currently receiving chemotherapy or other active cancer treatment

What participation looks like

You would visit a hospital or medical center at the beginning of the study, then again at 6 months and 12 months for check-ups and breathing tests. Between those visits, you would have brief phone or video calls with the study team at 3 and 9 months to check on how you are doing and report any flare-ups. The study lasts 12 months total, and the doctors will track how your lung disease changes over that time.

AI-generated summary from trial data · Jun 11, 2026 · Not medical advice

Tracking severe lung disease patterns across Brazil

What is this trial?

Do you qualify?

What participation looks like

Trial locations