Ultrasound imaging to evaluate neck lymph node response after chemotherapy and immunotherapy

This trial is studying whether contrast-enhanced ultrasound — a special imaging technique that uses sound waves to take detailed pictures of your neck — can accurately assess how well your lymph nodes are responding to neoadjuvant chemoimmunotherapy (chemotherapy and immunotherapy given before surgery). Researchers want to understand if this imaging method can help doctors decide whether you actually need neck surgery after your initial cancer treatment, or if the lymph nodes have responded well enough that surgery might not be necessary.

After chemotherapy and immunotherapy for head and neck cancer, doctors need to know whether the swollen lymph nodes in the neck have shrunk or disappeared. Currently, there isn't a reliable imaging method to determine this, so many patients may undergo unnecessary neck surgery. This trial aims to find out whether this special ultrasound technique can provide better, more accurate answers to help doctors make smarter treatment decisions.