Plain-English translation of NCT06727773 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether , a medication that may protect brain function, combined with a guided exercise program called Get Real & Heel, can help prevent or reduce thinking and memory problems during breast cancer chemotherapy. Many breast cancer survivors experience 'chemo brain'—difficulty concentrating, remembering things, or thinking clearly—and this study is exploring whether this medication and exercise combination might help protect your cognitive abilities during treatment.
About half of breast cancer patients develop noticeable thinking or memory problems during or after chemotherapy, affecting their quality of life and ability to work. This medication has shown promise in research for protecting brain health, and this trial will test whether combining it with exercise is a practical and effective way to help prevent these cognitive changes.
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You will be assigned to one of three groups: one receiving the medication plus guided exercise sessions with a therapist, one with access to recorded exercise videos, or one receiving the medication plus recorded exercise videos. Throughout your chemotherapy, you'll take the medication as prescribed, participate in or access exercise sessions, and complete thinking and memory tests at various points to see how well the treatment works. The study will also check blood markers and measure your physical fitness to understand how the treatment affects your brain and overall health.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
United States