Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(250 sites) United States
Yale Cancer Center, New Haven, Connecticut Orchard Healthcare Research Inc., Skokie, Illinois University of Kansas Medical Center Research Institute, Inc., Kansas City, Kansas Maryland Oncology Hematology, P.A., Silver Spring, Maryland Tufts Medical Center, Boston, Massachusetts University of Michigan Comprehensive Cancer Center Michigan Medicine, Ann Arbor, Michigan Minnesota Oncology Hematology, P.A., Minneapolis, Minnesota Memorial Sloan Kettering Cancer Center - MAIN, New York, New York Montefiore Medical Center, The Bronx, New York Providence Portland Medical Center, Portland, Oregon Penn State University Milton S. Hershey Medical Center, Hershey, Pennsylvania Prisma Health Cancer Institute, ITOR, CRU, Greenville, South Carolina Tennessee Oncology Nashville Midtown, Nashville, Tennessee UT Southwestern Medical Center, Dallas, Texas Texas Oncology, P.A. - Tyler, Tyler, Texas Virginia Oncology Associates, Norfolk, Virginia Blue Ridge Cancer Care, Roanoke, Virginia Wenatchee Valley Hospital & Clinics, Wenatchee, Washington Argentina
CEMIC Ciudad Autonoma, Buenos Aires Instituto Medico Especializado Alexander Fleming, Buenos Aires Clinica Universitaria Privada Reina Fabiola, Córdoba Centro de Investigaciones Medicas Mar del Plata, Mar del Plata Instituto Medico de la Fundacion Estudios Clinicos, Rosario Australia
Flinders Medical Centre, Bedford Park Monash Medical Centre Clayton, Clayton Townsville University Hospital, Douglas Peter MacCallum Cancer Centre, North Melbourne GenesisCare North Shore (Oncology), St Leonards St John of God Subiaco Hospital, Subiaco Wollongong Hospital, Wollongong Austria
LKH - Universitaetsklinikum Graz, Graz Medizinische Universität Innsbruck, Innsbruck Medizinische Universität Wien, Vienna St. Josef Krankenhaus Wien, Vienna Landesklinikum Wiener Neustadt, Wiener Neustadt Belgium
Institut Jules Bordet, Anderlecht Cliniques Universitaires Saint-Luc, Brussels Centre Hospitalier Universitaire de Liege, Liège Brazil
Centro de Oncologia - Unidade Brasilia - Hospital Sirio Libanes, Brasília ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira Sao Paulo, Brazil CEPON - Centro de Pesquisas Oncológicas de Santa Catarina, Florianópolis Fundação Doutor Amaral Carvalho, Jaú Liga Norte-Rio-Grandense Contra o Câncer, Natal Hospital de Clínicas de Porto Alegre, Porto Alegre Hospital São Lucas da PUCRS, Porto Alegre IMIP - Instituto de Medicina Integral Professor Fernando Figueira, Recife Hospital das Clínicas FMRP-USP, Ribeirão Preto INCA - Instituto Nacional de Câncer, Rio de Janeiro Obras Sociais Irmã Dulce - Hospital Santo Antônio, Salvador Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, Sao Jose Rio Preto Canada
Cité de la Santé de Laval, Laval Trillium Health Partners Credit Valley Hospital, Mississauga St. Mary's Hospital, Montreal CHUS - Hôtel-Dieu, Sherbrooke Mount Sinai Hospital, Toronto Mount Sinai Hospital, Toronto Sunnybrook Health Sciences Centre, Toronto University Health Network - Princess Margaret Cancer Centre, Toronto Chile
Centro de Investigacion del Maule, Region Del Maule Centro de Estudios Clinicos SAGA, Santiago FALP - Fundación Arturo López Pérez, Santiago Hospital Clinico Universidad de Chile, Santiago China
Beijing Cancer Hospital, Beijing Peking University Third Hospital, Beijing The First People's Hospital of Changzhou, Changzhou Fujian Cancer Hospital, Fuzhou Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou The First Affiliated Hospital of Zhejiang University school of medicine, Hangzhou Harbin Medical University Cancer Hospital, Harbin Anhui Provincial Cancer Hospital, Hefei Shandong Cancer Hospital, Jinan Gansu Provincial Cancer Hospital, Lanzhou Lanzhou University Second Hospital, Lanzhou Linyi Cancer Hospital, Linyi Meizhou People's Hospital, Meizhou Czechia
Masarykuv onkologicky ustav, Brno Fakultni nemocnice Hradec Kralove, Hradec Králové Fakultni nemocnice Olomouc, Olomouc Fakultni nemocnice v Motole, Prague France
Institut Sainte Catherine, Avignon CHU de Brest - Hopital de la Cavale Blanche, Brest Centre Georges François Leclerc, Dijon CHU Grenoble - Hopital Michallon, Grenoble Centre Oscar Lambret, Lille Hopital Prive Jean Mermoz, Lyon CHU Montpellier, Saint Eloi, Montpellier Chru De Nantes Hotel-Dieu, Nantes Hôpital Européen Georges Pompidou, Paris Hôpital Saint-Antoine, Paris Institut Mutualiste Montsouris, Paris CHU Bordeaux - Hôpital Haut-Lévêque, Pessac CHU Poitiers - Hôpital la Milétrie, Poitiers Institut de Cancérologie de Strasbourg Europe - ICANS, Strasbourg Germany
Charité Universitätsmedizin Berlin - Campus Virchow-Klinikum, Berlin Vivantes Klinikum im Friedrichshain, Berlin Klinikum Chemnitz gGmbH, Chemnitz Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden Universitaetsklinikum Frankfurt Goethe-Universitaet, Frankfurt am Main Universitaetsklinikum Hamburg-Eppendorf, Hamburg Universitaetsklinikum Heidelberg, Heidelberg Universitaetsklinikum Leipzig AoeR, Leipzig Klinikum rechts der Isar der TU Muenchen, München Italy
Presidio Ospedaliero Garibaldi Nesima, Catania Azienda Ospedaliera Universitaria Careggi, Florenze IRCCS Ospedale Policlinico San Martino, Genova Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda), Milan Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Ospedale San Raffaele, Milan A.O.U. Policlinico di Modena, Modena Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli", Naples IOV - Istituto Oncologico Veneto IRCCS, Padova Azienda Ospedaliero Universitaria Pisana, Pisa Azienda Unità Sanitaria Locale- Ravenna, Ravenna Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome Istituto Clinico Humanitas, Rozzano Japan
Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Bunkyō City National Cancer Center Hospital, Chūōku Gifu University Hospital, Gifu Hiroshima City Hiroshima Citizens Hospital, Hiroshima National Cancer Center Hospital East, Kashiwa-shi JCHO Kyushu Hospital, Kitakyushu Kochi Health Sciences Center, Kochi Cancer Institute Hospital of JFCR, Kōtoku NHO Shikoku Cancer Center, Matsuyama Aichi Cancer Center Hospital, Nagoya Miyagi Cancer Center, Natori-shi Niigata Cancer Center Hospital, Niigata Osaka International Cancer Institute, Osaka Netherlands
Antoni van Leeuwenhoek, Amsterdam Medisch Centrum Leeuwarden, Leeuwarden Erasmus Medisch Centrum, Rotterdam Norway
Haukeland University Hospital, Bergen Akershus universitetssykehus HF, Lørenskog Oslo Universitetssykehus HF, Ullevål, Oslo St. Olavs Hospital Hf, Universitetssykehuset i Trondheim, Trondheim Poland
Beskidzkie Centrum Onkologii im.Jana Pawla II, Bielsko-Biala Szpital Wojewodzki im. Mikolaja Kopernika, Koszalin Wielkopolskie Centrum Onkologii, Poznan Narodowy Instytut Onkologii im. Marii Sklodowskiej Curie Panstwowy Instytut Badawczy W Warszawie, Warsaw Warszawski Uniwersytet Medyczny, Warsaw Portugal
Hospital da Senhora da Oliveira Guimarães, E.P.E., Guimarães Fundação Champalimaud, Lisbon Unidade Local de Saúde de Santa Maria, E.P.E. - Hospital de Santa Maria, Lisbon Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto Romania
Institutul Clinic Fundeni, Bucharest Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj Napoca, Cluj-Napoca S.C Medisprof S.R.L, Cluj-Napoca Centrul de Oncologie Sfantul Nectarie Craiova, Craiova Institutul Regional de Oncologie Iasi, Iași S.C Ovidius Clinical Hospital S.R.L, Ovidiu S.C. Sigmedical Services SRL, Suceava South Korea
Chungbuk National University Hospital, Cheongju-si Kyungpook National University Chilgok Hospital, Daegu National Cancer Center, Goyang-si Chonnam National University Hwasun Hospital, Hwasun-gun Gachon University Gil Medical Center, Incheon Jeonbuk national university hospital, Jeonju Seoul National University Bundang Hospital, Seongnam CHA Bundang Medical Center, CHA University, Seongnam-si Korea University Anam Hospital, Seoul Seoul National University Hospital, Seoul Severance Hospital, Yonsei University Health System, Seoul Asan Medical Center, Seoul Samsung Medical Center, Seoul Spain
ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona Hospital Clinic de Barcelona, Barcelona Hospital del Mar, Barcelona Hospital Universitari Vall d'Hebron, Barcelona Hospital Universitario Reina Sofia, Córdoba Hospital General Universitario de Elche, Elche ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat Hospital General Universitario Gregorio Marañon, Madrid Hospital Universitario La Paz, Madrid Hospital Universitario Ramon y Cajal, Madrid MD Anderson Cancer Centre, Madrid Hospital Regional Universitario de Malaga, Málaga Hospital General Universitario Morales Meseguer, Murcia
Taiwan
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City National Cheng Kung University Hospital, Tainan Taipei Veterans General Hospital, Taipei National Taiwan University Hospital, Taipei Chang Gung Memorial Hospital,Linkou, Taoyuan Thailand
Siriraj Hospital, Bangkoknoi Songklanagarind Hospital, Hat Yai Chulabhorn Hospital, Laksi King Chulalongkorn Memorial Hospital, Pathum Wan Turkey (Türkiye)
Medical Park Seyhan Hospital, Adana Ankara City Hospital, Ankara Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital, Ankara Hacettepe University Medical Faculty, Ankara Dicle University, Medical faculty, Diyarbakır Ataturk University Medical Faculty, Erzurum Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul Medipol University Medical Faculty, Istanbul İ.E.Ü. Medicalpoint İzmir Hastanesi, Izmir Medical Park Samsun Hastanesi, Samsun United Kingdom
Queen Elizabeth Hospital, Birmingham Velindre Cancer Centre, Cardiff Ninewells Hospital, Dundee Castle Hill Hospital, Hull St James's University Hospital, Leeds Sarah Cannon Research Institute UK, London University College London Hospitals, London Altnagelvin Area Hospital, Londonderry The Christie Hospital, Manchester Royal Marsden Hospital, Sutton Vietnam
Hanoi Oncology hospital, Hanoi National Cancer Hospital, Hanoi Cho Ray Hospital, Ho Chi Minh City HCMC Oncology Hospital, Ho Chi Minh City HCMC University Medical Center, HoChiMinh Key details Collaborators
Merck Sharp & Dohme LLC
Enrollment target
~726 participants
Primary completion
June 2028
Liaoning Cancer Hospital & Institute, Shenyang
The Second Affiliated Hospital of Soochow University, Suzhou Shanxi Provincial Cancer Hospital, Taiyuan Shanxi Provincial People's Hospital, Taiyuan Tianjin Medical University Cancer Institute & Hospital, Tianjin The Affiliated Cancer Hospital of Xinjiang Medical university, Ürümqi Hubei Cancer Hospital, Wuhan Wuxi 4th People's Hospital, Wuxi The First Affiliated Hospital of Xian Jiaotong University, Xi'an The First Affiliated Hospital of Xiamen University, Xiamen Fudan University Shanghai Cancer Center, Xuhui District Xuzhou Central Hospital, Xuzhou General Hospital of Ningxia Medical University, Yinchuan The First Affiliated Hospital of Zhengzhou University, Zhengzhou Hopital Rangueil, Toulouse IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino Azienda Ospedaliera Card. G. Panico, Tricase Kindai University Hospital, Osakasayama-shi
Hokkaido University Hospital, Sapporo Osaka University Hospital, Suita-shi Kanagawa Cancer Center, Yokohama The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
Hospital Universitario Central de Asturias, Oviedo
Hospital Universitario de Navarra, Pamplona Hospital Universitario Virgen del Rocio, Seville Hospital Clinico Universitario de Valencia, Valencia