Building a research database of people with allergic and immune diseases

Plain-English translation of NCT06732414 on ClinicalTrials.gov ↗ ·

What is this trial?

This is a long-term study that builds a research database—called a biorepository—by collecting samples and health information from people with allergies and related immune conditions. Researchers will use these donated samples and data to study why these diseases happen and to test new treatments. Your participation helps create a valuable resource that many scientists can use to improve care for allergic diseases.

Many people struggle with allergies, asthma, eczema, and sinus problems, but we still don't fully understand what causes these diseases or how to treat them best. By collecting samples and information from many people with these conditions, researchers can study the biology behind allergic diseases and develop better treatments in the future.

Do you qualify?

You likely qualify if…

you are between ages 3 and 100
you have been diagnosed with an allergic disease, asthma, eczema, sinus problems, or other immune condition, or you have had a severe allergic reaction to food, insect stings, medications, or environmental allergens
you are able to give informed consent (or your parent or guardian can consent for you if you are a child)
you have or are willing to find a primary care doctor outside the NIH who will manage your regular medical care
you are willing to allow your blood, skin samples, nasal fluids, and tissue samples to be stored and used for future medical research

You likely don't qualify if…

you are pregnant or breastfeeding (for certain procedures like biopsies or skin prick testing)
you are currently taking blood thinners that cannot be stopped before a procedure
you have uncontrolled asthma or serious health conditions that make procedures unsafe
you have a history of severe reactions to anesthesia or sedation
you have had recent abdominal surgery or have blood counts that are too low

What participation looks like

You will visit the NIH Clinical Center (or participate by telehealth or mail) for clinical evaluation and treatment of your allergic condition. During visits, doctors will perform standard care procedures like physical exams, allergy testing, and breathing tests; they will also collect extra samples—such as blood, nasal brushings, skin swabs, and sometimes tissue biopsies—specifically for the research database. After an initial set of visits, your regular medication management will transition to your primary care doctor, though researchers may continue to collect samples and follow-up information from you over time.

Building a research database of people with allergic and immune diseases

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)