Plain-English translation of NCT06733012 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a procedure that blocks signals in the splanchnic nerves—nerves that control how your body holds onto fluid—to see if it can help people with heart failure feel better and move around more easily. Researchers think that part of heart failure involves the body holding onto too much fluid in the belly area, and this new treatment might help redirect that fluid. The study will compare people who receive the nerve-blocking procedure to those who receive a sham (fake) procedure to see if it truly works.
Current heart failure treatments mainly focus on removing excess fluid from the body, but these approaches haven't worked as well as doctors hoped. Researchers believe this new treatment addresses a different part of the problem—how the body distributes fluid internally—which could help reduce congestion, improve your ability to exercise, and ease symptoms like shortness of breath.
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If you qualify, you will undergo an invasive exercise stress test to measure how your heart responds to activity. Then you will be randomly assigned to either receive the nerve-blocking procedure or a sham procedure. Half of the participants will have a catheter (thin tube) placed to block the splanchnic nerve, while the other half will undergo a similar procedure that doesn't actually block the nerve—this allows researchers to fairly measure the treatment's true benefit. You will be monitored for safety and your symptoms, activity level, and heart function will be tracked over time.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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