Plain-English translation of NCT06736028 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether a ketogenic diet (very high in fat, very low in carbohydrates) works better than a traditional low-fat diet for keeping weight off after you've lost it. Researchers want to understand how each diet affects your hunger levels and how many calories your body burns at rest.
Many people struggle to keep weight off after losing it. This trial exists to find out which type of diet—ketogenic or low-fat—might help people maintain their weight loss more successfully and feel less hungry while doing so.
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You'll start with a 4-week phase where you follow a low-calorie diet (using meal replacements) to lose at least 5% of your body weight. If you reach that goal, you'll be randomly assigned to follow either a ketogenic diet or a low-fat diet for 6 weeks, starting with a 2-week gradual transition back to regular food. Throughout the study, you'll have visits to the research center where researchers will measure your weight, hunger levels, and how many calories your body burns.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States
Sponsor
University of Alabama at Birmingham
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrollment target
~20 participants
Started
August 2025
Primary completion
December 2026
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Catia Martins, PhD
University of Alabama at Birmingham
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.