Recruiting

Testing higher doses of a diabetes medication for teenagers

Plain-English translation of NCT06739122 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

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Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This study is testing two higher doses of , an injectable medication that helps control blood sugar in teenagers with type 2 diabetes. Researchers want to see if these new dose options are safe, well-tolerated, and effective for young people whose diabetes is currently managed with diet, exercise, and other diabetes medications. The trial will last about 8 months.

Type 2 diabetes in young people is becoming more common, and doctors need more treatment options that work well and safely in teenagers. This medication has helped adults, but researchers need to find the right doses and confirm safety for younger patients.

Do you qualify?

You likely qualify if…

you have been diagnosed with type 2 diabetes and are currently managing it with diet, exercise, and metformin and/or basal insulin
your metformin or basal insulin dose has been stable for at least 8 weeks before you enroll
you weigh at least 50 kilograms (about 110 pounds)
your body mass index is above the 85th percentile for your age and sex

You likely don't qualify if…

you have type 1 diabetes instead of type 2 diabetes
you have a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
you have had a severe low blood sugar episode or episodes of low blood sugar unawareness in the last 6 months
you have a history of pancreatitis or gallbladder disease
you have taken weight-loss medications or supplements in the 8 weeks before screening

What participation looks like

You will receive injections of the medication under your skin at regular clinic visits over about 8 months. Your doctor will monitor your blood sugar levels, check how well the medication is working, and watch for any side effects. You'll need to have blood tests and check-ups to make sure the treatment is safe and helping control your diabetes.

AI-generated summary from trial data · Jun 20, 2026 · Not medical advice

Trial locations(51 sites)

United States

University of Arizona, Tucson, Arizona

Arkansas Childrens Hospital, Little Rock, Arkansas

Division of Endocrinology, Diabetes, and Metabolism, Los Angeles, California

UCLA Mattel Children's Hospital, Los Angeles, California

University of California, San Francisco, San Francisco, California