Exercise and a new antipsychotic combination to prevent weight gain

This trial is testing whether olanzapine-samidorphan, a combination antipsychotic medication, works better at preventing weight gain when paired with aerobic exercise. Researchers want to see if people who exercise regularly while taking this medication gain less weight than people taking the medication alone. The study will follow participants for 8 weeks and carefully measure weight, metabolism, and how well the medication controls psychiatric symptoms.

Antipsychotic medications can cause significant weight gain, which puts patients at risk for diabetes, heart disease, and other health problems. This trial is trying to find out whether pairing the medication with exercise can reduce this unwanted side effect and improve overall health outcomes.