Brain Radiation Surgery Plus Medication for Lung Cancer Spread to Brain

This trial is testing whether combining radiation surgery with osimertinib—a targeted medication that crosses into the brain—works better than the medication alone for treating lung cancer that has spread to the brain. You would be randomly assigned to receive either the medication with radiation surgery, or the medication by itself. The goal is to see if adding this type of radiation treatment helps keep brain tumors under control longer.

When lung cancer spreads to the brain, patients need treatment that can reach both the brain and the rest of the body. Doctors want to know whether combining this targeted medication with radiation surgery gives patients better outcomes than using the medication alone.