Plain-English translation of NCT06744361 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
When someone's heart stops outside a hospital and is revived, the brain can suffer serious damage from lack of oxygen. This trial is testing whether S-ketamine, a sedative medication, can better protect the brain than , the sedative commonly used today. Researchers will compare how well each medication prevents brain injury and improves long-term recovery in cardiac arrest survivors.
Even when doctors successfully restart a patient's heart after cardiac arrest, brain damage often causes lasting problems or death. Currently, there are no proven medications specifically designed to protect the brain during this critical recovery period. This trial exists to see whether this medication might fill that gap and help more cardiac arrest survivors recover better.
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As a participant, you would receive one of the two sedative medications through an IV line during emergency care. The research team would then track your recovery over 180 days, monitoring brain injury markers and your neurological condition. You would be followed up at the hospital and after discharge to see how well you recover and how the medication affected your long-term outcomes.
AI-generated summary from trial data · Aug 9, 2026 · Not medical advice
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