Plain-English translation of NCT06747091 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new catheter ablation procedure for people with persistent atrial fibrillation—a condition where the heart's upper chambers beat irregularly for more than a week. The procedure uses a special catheter with a new lattice-tip design that can switch between two types of energy (radiofrequency and pulsed field ablation) to treat the problem. Researchers want to find out which ablation strategy works best to prevent the irregular heartbeat from coming back.
Persistent atrial fibrillation can increase the risk of stroke and other serious complications, and current treatments don't work for everyone. This trial aims to determine whether treating additional areas of the heart beyond the pulmonary veins—using this new dual-energy catheter—leads to better outcomes and fewer recurrences of the irregular heartbeat.
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You will undergo a catheter ablation procedure using the new specialized catheter, and you'll be randomly assigned to one of three treatment approaches that target different areas of the heart. Before, during, or after the procedure, you will have a small monitoring device (implantable loop recorder) placed under your skin to continuously check for any return of the irregular heartbeat. You will need to attend follow-up visits and allow the research team to monitor your heart rhythm over time to see how well the treatment works.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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