Plain-English translation of NCT06756490 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is a Phase I trial testing HY-2003, a medication made of deoxycholic acid wrapped in tiny fat-like particles, delivered by injection directly into excess fat under the chin. The study will evaluate whether this treatment is safe and how well it works at different doses compared to a placebo (dummy injection) and a positive control. Researchers will also study how the body processes this medication.
Many people have excess fat under the chin that they are unhappy with, and current treatment options are limited. This trial will help determine if this new injectable medication could offer a safe and effective non-surgical option for those with moderate to severe submental fullness.
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You will receive a series of injections under your chin at study visits; the exact number of visits and injections will depend on which treatment group you are assigned to. You will be randomly assigned to receive either the new medication at different doses, a positive control medication, or a placebo, and neither you nor the evaluators will know which treatment you're getting. The study will include safety check-ins, blood tests, and photographs to evaluate how the treatment affects the appearance and feel of the under-chin area over time.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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