Plain-English translation of NCT06758830 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether rectal cancer patients can preserve their rectum (the lower part of the colon) without surgery if they respond well to chemotherapy and radiation therapy. About half of patients who receive this combination treatment and achieve a complete or near-complete response may be able to avoid surgery entirely and instead be monitored closely over time. The trial compares this watch-and-wait approach to the standard treatment of surgery.
Rectal cancer surgery can cause serious long-term problems like bowel dysfunction and loss of normal bodily functions. This trial exists to see whether the new treatment approach can give patients the same survival and quality of life outcomes while letting them keep their rectum and avoid surgery altogether.
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If you are selected for the experimental group, you will receive 12 weeks of combined with pelvic radiation therapy. After treatment ends, your doctors will carefully assess your response using physical examination, MRI scans, and endoscopy (a camera to look inside your rectum). If you have a complete or near-complete response, you will be monitored closely without surgery—this is the 'watch-and-wait' approach. If you do not respond well, you will then have surgery. Throughout the trial, you will have regular follow-up visits to check your health and monitor for any signs of cancer returning.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
Lithuania