New combination treatment for advanced stomach cancer

Plain-English translation of NCT06760858 on ClinicalTrials.gov ↗ ·

What is this trial?

This trial is testing a new combination approach to treating locally advanced stomach cancer that has not spread to distant parts of the body. The treatment combines chemotherapy drugs (called ), a medication called that helps your immune system fight cancer, and a procedure called HIPEC—which is a heated liquid wash applied directly inside the abdomen during surgery. Researchers want to see if adding this medication to the standard treatment improves how many patients survive cancer-free for three years.

Locally advanced stomach cancer is difficult to treat and many patients do not survive long-term with current treatments alone. This trial exists to test whether the medication can help the immune system work better alongside chemotherapy to improve outcomes for patients with this serious diagnosis.

Do you qualify?

You likely qualify if…

you have been newly diagnosed with stomach cancer that has not spread to distant organs and have not received any previous cancer treatment
you are between 18 and 80 years old and in good enough health to tolerate chemotherapy (ECOG performance status 0-1)
your blood counts are healthy enough (white blood cells, platelets, and hemoglobin all within acceptable ranges)
your liver and kidney function are normal or only mildly reduced
you are willing to use effective contraception during the study if you can become pregnant or father a child
you can commit to follow-up visits, blood tests, and tissue sampling over the study period

You likely don't qualify if…

you have already received chemotherapy, radiation therapy, or immunotherapy before this trial
cancer has spread to your liver, lungs, bones, brain, or other distant sites
you have had a stomach perforation, severe blockage, or uncontrollable diarrhea in the past six months
you are currently taking high-dose steroids or other immune-suppressing medications (except for hormone replacement or short-term preventive steroids)
you have an active autoimmune disease or have participated in another cancer drug trial within the past month

What participation looks like

If you enroll, you will receive three cycles of chemotherapy ( regimen) combined with the medication over nine weeks, with each cycle lasting three weeks. You will also undergo the heated abdominal wash (HIPEC) procedure. After initial treatment, your doctors will assess how well the cancer has responded and decide whether surgery is possible; if so, you will have surgery followed by another HIPEC treatment. You will have regular blood tests, imaging scans, and doctor visits throughout the trial to monitor how you are tolerating treatment and how your cancer is responding. If your cancer does not respond or gets worse, your medical team will discuss other treatment options with you.

New combination treatment for advanced stomach cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(2 sites)