Plain-English translation of NCT06761937 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is a Phase I trial testing thermoradiotherapy — a combination of mild heat therapy and radiation — for people with advanced head and neck cancer. Researchers want to see if gently heating the tumor area to fever-like temperatures can make radiation more effective and help shrink tumors better. This approach may be especially helpful for older patients or those who cannot safely receive certain chemotherapy drugs.
Advanced head and neck cancers are often difficult to treat and have low survival rates. Many patients receive chemotherapy alongside radiation, but this can cause serious side effects — especially in older adults. This trial exists to find a gentler way to boost radiation's power using heat, which might work better for patients who cannot tolerate chemotherapy.
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You will receive standard radiation therapy to your tumor area, plus an additional heat therapy session once per week. The heat therapy uses microwaves to gently warm the tumor to fever-like temperatures (around 40–44°C), which makes the radiation more effective. The trial will enroll 30 participants total, and your doctor will monitor you closely throughout treatment and afterward to track how well the combined approach works and any side effects you experience.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
Netherlands