Testing a new drug combination for breast cancer that has spread to the brain

Plain-English translation of NCT06764940 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing , a new medication, to see if it can help treat HER2-negative breast cancer that has spread to the brain. Researchers want to know whether this medication works better when given alone or when combined with another drug called capecitabine. The study will track how well the treatment shrinks brain tumors and what side effects patients experience.

Breast cancer that spreads to the brain is very difficult to treat, and there are limited options for patients with HER2-negative tumors. This trial exists to find out whether this medication can cross into the brain effectively and help control these dangerous tumors.

Do you qualify?

You likely qualify if…

you have been diagnosed with HER2-negative metastatic breast cancer that has spread to your brain
you have at least one measurable brain tumor that is at least 1 centimeter in size, confirmed by MRI
you are 18 years old or older and in good enough health to tolerate treatment
you have received 3 or fewer previous chemotherapy treatments for advanced cancer
you have adequate liver, kidney, and blood cell function based on recent lab tests
if you can become pregnant, you agree to use reliable birth control during and for 6 months after the study

You likely don't qualify if…

you have cancer that has spread to the protective lining around your brain and spinal cord (leptomeningeal metastasis)
you have brain tumors in critical locations where swelling could cause serious harm, such as near the brain stem
you have frequent, poorly controlled seizures despite treatment, or are showing signs of worsening neurological problems
you have had bleeding inside your brain within the past 3 months, or significant bleeding elsewhere in your body within the past 4 weeks
you have had major surgery within the past 4 weeks, or have received cancer treatment within 2 weeks before starting the study

What participation looks like

The study has two stages. In stage one, researchers will test the medication alone and in two different combinations to see which works best and is safest. In stage two, participants will receive the combination that worked best from stage one. Throughout the trial, you will visit the hospital or clinic regularly for blood tests, brain MRIs, and checkups to see how you are responding to treatment. The study will involve about 120 patients total across multiple medical centers.

AI-generated summary from trial data · Aug 22, 2026 · Not medical advice

Testing a new drug combination for breast cancer that has spread to the brain

What is this trial?

Do you qualify?

What participation looks like

Trial locations