Weight loss medication and diet for people with mild Crohn's disease

This trial is testing whether tirzepatide, an injectable medication that helps with weight loss, combined with a Mediterranean-style diet can help improve Crohn's disease symptoms in people with mild disease. Participants are already taking biologic medications (like infliximab or adalimumab) to control their Crohn's, and this study looks at whether adding the medication and dietary changes on top of that existing treatment might provide extra benefit. The study will last up to 12 weeks.

People with Crohn's disease who are overweight or have a higher body mass index often struggle with their symptoms, and there is limited evidence about whether weight loss itself—through medication and diet—might help reduce inflammation and improve how they feel alongside their current medications.