Plain-English translation of NCT06776081 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is investigating tiny particles called extracellular vesicles that are released from fat tissue in people with obesity. Researchers believe these particles may harm how blood vessels function, and they want to learn whether losing weight reduces these particles and improves blood vessel health.
Obesity increases the risk of heart disease and other metabolic problems, but doctors don't fully understand all the harmful processes happening inside the body. This study aims to identify new warning signs in the blood that could help predict and prevent heart disease in people with obesity.
You likely qualify if…
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The study has two phases. In Phase 1, you would visit the lab once to have blood drawn and undergo a test of your blood vessel function (using ultrasound). In Phase 2, if you have obesity, you would commit to a 12-week structured weight loss program while researchers track changes in your blood particles and blood vessel health through repeat visits and blood tests.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Sponsor
University of Colorado, Boulder
Enrollment target
~84 participants
Started
July 2024
Primary completion
June 2027
Age range
40 Years and older
Last updated on clinicaltrials.gov in April 2026.
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Central contact
Jared Greiner, MS
University of Colorado, Boulder
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.