Plain-English translation of NCT06777914 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are looking for genetic mutations—changes in your DNA—that may increase the risk of developing liver cancer or cholestatic liver disease (a condition where bile doesn't flow properly through the liver). By studying blood and tissue samples from 600 people, this study aims to identify which genetic changes are most important in these diseases so that future treatments can be developed.
Some people develop liver cancer or severe cholestasis without obvious causes like hepatitis or alcohol use. Researchers believe that inherited genetic mutations may play a role, but they don't yet know which genes are most important or how common these changes are. This study will help answer those questions.
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You will have your medical history reviewed and provide blood and tissue samples for genetic testing. Researchers will also collect results from your imaging tests (ultrasound, CT, or MRI), liver function tests, and sometimes a non-invasive scan to measure liver scarring (FibroScan). If standard genetic testing doesn't find a clear answer but doctors still suspect a genetic cause, you may have more advanced genetic sequencing done. All information will be stored securely, and you may receive genetic counseling to discuss any findings.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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