Testing new cancer medications for advanced lung cancer

Plain-English translation of NCT06780085 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

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Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing three different investigational medications—, , and docetaxel—to see which works best for people with advanced lung cancer whose disease has stopped responding to previous treatments. You would receive one of these medications every three weeks by intravenous infusion (through an IV). The goal is to find out whether one of these treatments is more effective than the others.

Many people with advanced lung cancer eventually stop responding to standard treatments. This trial is trying to find new options that might help people whose cancer has progressed after prior chemotherapy and immunotherapy.

Do you qualify?

You likely qualify if…

you have been diagnosed with stage 4 nonsquamous non-small cell lung cancer
your cancer has progressed despite prior treatment with PD-1/PD-L1 immunotherapy and platinum-based chemotherapy
you do not have specific genetic mutations (EGFR, ALK, or ROS1) that would require targeted therapy
you have measurable disease that can be assessed by scans
you are at least 18 years old and have an overall health status of 0 or 1 (able to carry out normal daily activities)
you have a life expectancy of at least 3 months

You likely don't qualify if…

you have small cell lung cancer or mixed lung cancer with small cell elements
you have had radiation therapy to your lungs
you have severe heart or lung problems that are not controlled
you have lingering side effects from previous cancer treatments that have not recovered to mild levels or better
you have severe allergies to the study medications

What participation looks like

You would be randomly assigned to receive one of the three medications. Each medication is given by IV infusion every three weeks, and you would continue receiving it until your cancer progresses or you need to stop for safety reasons. You would have regular clinic visits to receive your infusions, have blood tests, and have scans to monitor how your cancer is responding. The trial will also require tissue samples from your tumor before treatment begins.

Testing new cancer medications for advanced lung cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(32 sites)