Testing an online brain health check-in tool for older adults

Plain-English translation of NCT06780917 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated July 2026 · How we translate trials

What is this trial?

Researchers are testing whether a computer-based tool called Creyos can reliably measure changes in thinking and memory skills over time in older adults. The study will compare how well this online tool matches traditional in-person memory and thinking tests (the gold standard) in people with mild cognitive impairment, those who have recovered from depression, and healthy older adults.

Right now, doctors use paper-and-pencil tests done in an office to measure thinking and memory problems, but these can be time-consuming and hard to repeat frequently. This trial is checking whether an easier, online version could catch important changes in brain health more conveniently, especially over several years.

Do you qualify?

You likely qualify if…

you are 60 years or older (65 or older if you have a history of depression)
you speak and read English fluently
you have been diagnosed with mild cognitive impairment, or you had depression that is now in remission (no current symptoms), or you are healthy with no history of major mental illness
you have a study partner — a family member or close friend — who sees you regularly and can help with the research

You likely don't qualify if…

you have a diagnosis of schizophrenia, bipolar disorder, or obsessive-compulsive disorder
you have been diagnosed with alcohol or substance use disorder in the past 12 months
you have had a stroke, seizure disorder, or multiple sclerosis
you are currently experiencing depression symptoms or have taken a medication to improve memory within the past 6 weeks
you have significant uncontrolled medical conditions like diabetes or high blood pressure

What participation looks like

You will come to the clinic once a year for an in-person thinking and memory test (the traditional way), and you'll also complete the online Creyos assessment four times per year from home or wherever is convenient for you. This continues for up to five years, allowing researchers to compare how well the online tool tracks changes compared to the standard in-person tests.

AI-generated summary from trial data · Jul 2, 2026 · Not medical advice

Trial locations(3 sites)

Canada

St. Michael's Hospital, Toronto, Ontario

University Health Network, Toronto, Ontario

Centre for Addiction and Mental Health, Toronto, Ontario