Plain-English translation of NCT06782464 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial compares two treatments for shoulder pain and stiffness caused by spasticity—a condition where muscles become tight and overactive after stroke, traumatic brain injury, or spinal cord injury. One treatment uses onabotulinumtoxinA (a medication that relaxes overactive muscles), while the other uses cryoneurolysis, a procedure that freezes specific nerves to reduce muscle overactivity. Both treatments are guided by ultrasound imaging to target the exact muscles and nerves causing your shoulder problems.
Long-term spasticity can cause permanent muscle shortening, joint stiffness, and severe pain that makes it hard to care for yourself. While botulinum toxin is commonly used, cryoneurolysis (freezing nerves) is a newer approach that may offer similar or better results without needing repeated injections. This trial will help doctors understand which treatment works best for shoulder pain and function.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive either botulinum toxin injections or cryoneurolysis treatment, both guided by ultrasound. The procedure itself is a one-time or single-session intervention performed by a trained doctor. You will then attend multiple follow-up evaluation sessions and participate in a rehabilitation program at the study center to track improvements in your shoulder pain, muscle tightness, and ability to perform daily activities. The study team will monitor your progress over time to see which treatment works best.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
Luxembourg