Plain-English translation of NCT06782529 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether people with knee arthritis and obesity can get good results from a lower dose of corticosteroid injections compared to the standard dose. Corticosteroid injections are placed directly into the knee joint to reduce inflammation and pain. The study will measure whether the lower dose works just as well as the standard dose for reducing pain and improving how well your knee functions.
Doctors want to know if they can use less of this medication while still helping patients feel better, since using lower doses might reduce side effects, especially for people living with obesity who may have other health conditions.
You likely qualify if…
You likely don't qualify if…
You will receive a steroid injection directly into your knee joint. Half of the participants will receive a standard dose, and half will receive a lower dose. After the injection, the research team will follow up with you to measure your pain level and how well your knee is working over time. The study compares these two groups to see if the lower dose is just as effective as the standard dose.
AI-generated summary from trial data · Aug 4, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
Mayo Clinic
Enrollment target
~40 participants
Started
January 2025
Primary completion
January 2027
Age range
55 Years – 85 Years
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jeffrey P Nadwodny, DO
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.