Plain-English translation of NCT06782724 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing — a guided psychological treatment using a naturally occurring substance — to help reduce depression and emotional distress in people with serious long-term diseases like COPD, ALS, MS, and advanced Parkinson's disease. Recent research has shown promising results with this medication in cancer patients dealing with similar anxiety and hopelessness. The trial wants to see if the treatment can work safely and effectively for people with these other serious conditions.
People with severe chronic illnesses often experience severe depression, anxiety about dying, and loss of hope — but standard antidepressants and talk therapy don't always help enough. Researchers are investigating whether this medication, given with professional support, might offer faster and more lasting relief.
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You would attend three preparation counseling sessions to prepare emotionally and mentally. Then you would receive one dose of the medication in a supervised, supportive setting with a trained therapist present. After that, you'd attend two integration sessions to process your experience. Several weeks later, you would receive a second dose, followed by three more integration sessions. Throughout the study, you'll complete questionnaires and assessments to track changes in your mood, anxiety, and quality of life. The entire process spans several months.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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