Plain-English translation of NCT06783491 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing a new combination approach for advanced colon cancer that hasn't spread beyond the abdomen. The study compares three groups: one receiving FOLFOX chemotherapy before and after surgery plus a special heated chemotherapy treatment during surgery, one receiving FOLFOX before and after surgery without the heated treatment, and one receiving surgery followed by standard care. The goal is to see whether adding this heated chemotherapy can prevent the cancer from coming back.
People with locally advanced colon cancer often have cancer return even after surgery and standard chemotherapy. Researchers believe that adding heated chemotherapy directly into the abdomen during surgery might work better at stopping cancer cells from surviving and coming back later.
You likely qualify if…
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You will receive chemotherapy pills or infusions for about 12 weeks, followed by surgery to remove the tumor and surrounding tissue. If you are in the group receiving heated chemotherapy, doctors will deliver warm chemotherapy directly into your abdomen during surgery. After surgery, you will receive another 12 weeks of chemotherapy. Throughout the trial, you will have blood tests, imaging scans, and follow-up visits to monitor how well the treatment is working and check for any side effects. The study will track your health for 3 years to see whether the cancer returns.
AI-generated summary from trial data · Jul 9, 2026 · Not medical advice
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