Plain-English translation of NCT06784167 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is studying how your immune system bounces back after CAR-T cell therapy, a powerful treatment for certain blood cancers. Researchers want to understand whether vaccines—like pneumococcal and tetanus shots—work as well in patients who have had this treatment, and how your body's infection-fighting ability recovers over time.
After CAR-T therapy, the immune system needs time to rebuild and start working normally again. Doctors need to know when it's safe and effective to vaccinate these patients, and whether the vaccines actually protect them the way they do in people who haven't had this treatment.
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You will have blood drawn before your CAR-T therapy and then at 6 months and 1 year after receiving vaccines. During the study, you may receive up to 3 doses of pneumococcal and/or tetanus vaccines according to your doctor's standard care plan. Researchers will review your medical records and test your blood to measure how well your immune system is responding to the vaccines.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States
Sponsor
OHSU Knight Cancer Institute
Collaborators
Oregon Health and Science University
Enrollment target
~45 participants
Started
March 2025
Primary completion
January 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2025.
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