Plain-English translation of NCT06784388 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing deep brain stimulation (DBS) — a surgical procedure that implants a small device to deliver electrical pulses to specific areas of the brain — for people with severe depression that has not improved with standard antidepressant medications. Researchers will customize the exact location and settings of the device for each patient based on brain scans and electrical recordings. The study will track how well this personalized approach reduces depression symptoms over more than a year.
Many people with severe depression do not respond to antidepressant drugs, even after trying multiple medications. This trial aims to find out whether personalizing the brain stimulation device to each patient's unique brain can offer relief when other treatments have failed.
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Over about 16 months, you would undergo four main phases: first, a week of brain imaging and symptom assessments; second, a 2-week hospital stay for electrode implantation and recording; third, over 14 months of DBS device implantation and treatment with regular check-ins every 2 weeks; and finally, a 2-month period where the device is turned off to see if symptoms return. Throughout, you will complete depression symptom questionnaires and have frequent follow-up visits with the research team.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
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