Using tumor oxygen levels to personalize cancer radiation treatment

This trial is testing whether a special blood test that measures oxygen levels in your tumor can help doctors decide if you'll benefit from adding oxygen-boosting treatment to your radiation therapy. Right now, doctors don't have a reliable way to know which patients have tumors with low oxygen—a condition that makes radiation less effective. This study uses a gene signature (a pattern of genes that shows hypoxia) to identify these patients so they can receive personalized treatment.

Some cancers have low-oxygen areas that resist standard radiation therapy, but doctors currently have no simple way to identify these patients. This trial exists to validate a test that could help doctors spot which patients would benefit from adding hypoxia-modifying treatment alongside radiation, potentially improving survival and outcomes.