Plain-English translation of NCT06790329 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This pilot study is testing a new endoscopic procedure that combines two techniques: fundal mucosal ablation (which targets a part of the stomach that affects hunger hormones) and endoscopic sleeve gastroplasty (which makes the stomach smaller). The goal is to see if combining these two approaches helps people with obesity lose more weight than either procedure alone, while keeping the procedure safe.
Standard endoscopic weight-loss procedures work reasonably well, but they don't achieve the same level of weight loss as traditional surgery. This trial exists because doctors believe that by combining two endoscopic techniques—especially one that reduces hunger hormones—they may be able to improve weight loss results while still offering a less invasive option than surgery.
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If you are accepted into this trial, you will undergo a single procedure where doctors use an endoscope (a thin, flexible camera) to perform two techniques inside your stomach while you are under general anesthesia. First, they will ablate (remove) tissue from the upper part of your stomach to reduce hunger hormones, and then they will create a sleeve-like shape in your stomach to make it smaller. After the procedure, you will be monitored for safety and effectiveness, with follow-up visits to track your weight loss and any side effects.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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