Comparing two breathing machine settings for severe lung failure

Plain-English translation of NCT06790875 on ClinicalTrials.gov ↗ · Source last updated January 2025 · Translation generated October 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study is testing two different ventilation modes — ways of setting a mechanical breathing machine — in adults who have severe acute lung failure (ARDS). Researchers want to understand how Low Tidal Volume ventilation and Airway Pressure Release Ventilation affect how the lungs work and heal. By comparing these two approaches, they hope to find which setting helps patients recover better.

Severe acute lung failure is a life-threatening condition where the lungs cannot get enough oxygen into the blood. Doctors use mechanical ventilation (breathing machines) to help, but finding the best settings is challenging. This trial exists to determine which ventilation approach is gentler on lung tissue and helps patients improve more safely.

Do you qualify?

You likely qualify if…

you have been diagnosed with acute respiratory distress syndrome (ARDS) according to the 2023 medical definition
you are between 18 and 80 years old
you have low blood oxygen levels requiring mechanical ventilation
you have been on a breathing machine for no more than 12 hours
you (or your family) are able to give informed consent to participate

You likely don't qualify if…

you are under 18 or over 80 years old
you have untreated shock or severe heart problems
you have chronic lung diseases like COPD, pulmonary embolism, or severe heart rhythm problems
you have a pacemaker, defibrillator, or extensive chest skin damage that would prevent safe monitoring
you are pregnant or breastfeeding

What participation looks like

As a participant, you would be randomly assigned to receive one of two ventilation settings on your breathing machine. The research team would carefully monitor how your lungs respond using specialized sensors that measure lung function. You would likely experience both ventilation approaches during the study (called a crossover design) so doctors can fairly compare which works better for you. The study involves close medical monitoring while you are hospitalized and on mechanical ventilation.

AI-generated summary from trial data · Oct 7, 2026 · Not medical advice

Trial locations(1 site)

China

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei