Plain-English translation of NCT06793488 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers want to understand what happens in the brain when someone stops drinking alcohol and how anxiety changes during recovery. This study uses brain imaging and a medication called disulfiram—which is already approved by the FDA to help people stay sober—to track these changes over time. The team will compare brain activity in people with alcohol use disorder to healthy volunteers who don't have this condition.
Many people in recovery from alcohol use disorder experience anxiety, and doctors don't fully understand why this happens or how it changes as someone stays sober. This research could help explain the brain mechanisms behind this anxiety and eventually lead to better treatments to support recovery.
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If you join this study, you would take disulfiram (a daily medication) under supervision for three months. You would have brain imaging scans (MRI) at two timepoints: about one to two weeks after your last drink, and then again after three months of being alcohol-free. During the scans, you'll complete a brief mental task while researchers watch how your brain responds. The healthy volunteers in the study would have just one brain scan. The entire study lasts about three months.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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