Finding Better Ways to Track Charcot-Marie-Tooth Disease Progression

Charcot-Marie-Tooth disease (CMT) is a genetic nerve disorder that can gradually affect muscle strength and sensation. Right now, doctors mainly rely on physical exams and nerve tests to measure how the disease is progressing — but these tests can be slow and don't always catch subtle changes. This study is looking for biological markers (measurable signs in your body) that could provide a faster, more reliable way to track disease progression and test new treatments.

Current methods for measuring disease progression in Charcot-Marie-Tooth disease are limited and slow to show changes. Researchers have found promising early evidence that changes in skin cells and muscle imaging might reflect disease severity better than traditional exams, but this hasn't been tested in larger groups of patients yet. This trial aims to confirm whether these new markers could become practical tools for monitoring the disease.