Plain-English translation of NCT06797206 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study called MATRIARCH_CF is following women with cystic fibrosis through pregnancy and early parenthood, as well as their children from birth through age six. Because newer CF treatments like CFTR modulators are allowing more people with CF to have healthy pregnancies, researchers want to understand how pregnancy and raising children affects women with CF, and how children born to parents with CF develop over time. The study will use blood tests, lung function tests, imaging, and interviews to monitor health.
More people with cystic fibrosis are now becoming pregnant thanks to better treatments, but there is limited information about how pregnancy and parenthood affect their health, or how their children develop in the long term. This research will help doctors and families make better decisions about pregnancy and care.
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If you are a woman with CF, you would attend up to eight visits over 12-24 months during and after pregnancy, including blood tests, lung function tests, imaging scans, and interviews about your physical and emotional health. If you have a newborn or young child, they would have up to four visits over two years (birth to age two) or two visits for ages three to six, which may include blood tests, sweat tests, lung imaging, and other health assessments. Many of the tests are optional, and researchers will simply monitor your health—they will not change or provide any new treatments.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United Kingdom
Sponsor
Royal Brompton & Harefield NHS Foundation Trust
Collaborators
Cystic Fibrosis Trust, King's College London
Enrollment target
~60 participants
Started
June 2025
Primary completion
April 2028
Last updated on clinicaltrials.gov in October 2025.
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Central contact
Amy Downes
Royal Brompton Hospital and NHLI Imperial College London
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.