Gut bacteria and nerve damage recovery with ozone treatment

This research study is looking at the connection between your gut bacteria and chemotherapy-related nerve damage (the tingling, numbness, and pain in your hands and feet that sometimes happens after cancer treatment). Researchers want to understand whether ozone therapy—a new treatment delivered through the rectum—helps reduce these symptoms, and whether changes in your gut bacteria might explain why some people improve and others don't. You would be part of a larger study where some people receive ozone therapy and others receive a placebo (inactive treatment), and researchers will analyze your stool samples to study your gut bacteria over time.

Nerve damage from chemotherapy is a common and painful side effect that often limits cancer treatment and hurts quality of life, yet there are few effective treatments available. This study exists because early evidence suggests ozone therapy might help, and scientists believe your gut bacteria could play an important role in how well the treatment works.